Thomas Sanderson, Ph.D.
Associate Professor (TT)
Director for Basic Science Research
Thomas Sanderson, Ph.D.
Office Location450 E. Canfield
4348 Scott Hall
Detroit, MI 48201
Thomas Sanderson, Ph.D., is an Associate Professor and Director of Basic Science Research in the Emergency Medicine Department and Cardiovascular Research Institute. Dr. Sanderson's basic science research focuses on ischemic insults to the brain, including those caused by cardiac arrest, ischemic stroke, and neonatal hypoxia/ischemia. Dr. Sanderson has multiple ongoing projects funded by the NIH, foundations, and industry including:
The role mitochondrial fusion/fission dynamics in death of neurons during post-ischemic reperfusion. The development and clinical translation of a neuroprotective therapy that modulates the activity of mitochondria to reduce ischemia-reperfusion injury to the brain.
Regulation of mitochondrial electron transport chain proteins and the role of alternate isoforms and post-transitional modifications play in reactive oxygen species generation and neuronal cell death.
1997-2001 BS in Biomedical Sciences, Western Michigan University, Kalamazoo, MI
2002-2006 PhD in Physiology, Wayne State Univeristy, Detroit, MI
Education – Degrees, Licenses, CertificationsPh.D.
2007-2009 Postdoctoral Fellowship, Molecular Neuroscience
Department of Emergency Medicine, Wayne State University, Detroit, MI
Associate Professor (Research/Educator Tenure Track), Cardiovascular Research Institute and Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI.
August 2015- Present
Assistant Professor (Research/Educator Tenure Track), Cardiovascular Research Institute and Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI.
Nov. 2012-August 2015
Associate Faculty Appointment, Department of Physiology, Wayne State University, Detroit, MI.
October 2010- Present
Assistant Professor (Non-Tenure Research/Educator Track), Department of Emergency Medicine, Wayne State University, Detroit, MI.
January 2009-November 2012
Director of Basic Science Research, Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI.
Associate Director of Basic Science Research, Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI. Nov. 2012-April 2014
Primary Member, Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit MI.
June 2009- Present
MBG8770-Molecular Biology of Mitochondrial Disease (Apoptosis, Ischemia/Reperfusion Injury, and Neurodegenerative Diseases Sections). 2011-Present
BMS5550- Anatomy for Health Professionals (Neuroanatomy, Renal, and Gastrointestinal Anatomy Sections).
Yr I Physiology (Endocrinology Section)
“Research Excellence Award” recognizes research excellence and achievement by faculty in the School of Medicine. Awarded to 2 faculty members at each rank, 6 awards annually.
“Symposium Chair” at Neuroscience 2015 –Molecular Mechanisms Associated with Ischemia, Chicago, IL, USA.
“Young Investigator Award” for the presentation entitled “Modulation of Cytochrome c Oxidase Activity with Specific Infrared Light Wavelengths: Non-invasive Therapy for Reperfusion Injury” at the 2014 annual Resuscitation Science Symposium: 2014 American Heart Association Scientific Sessions. Chicago, Illinois USA.
“Mitochondria Symposium Award” for the presentation entitled “Modulation of Cytochrome c Oxidase Activity with Specific Infrared Light Wavelengths: Non-invasive Therapeutic Applications for Reperfusion Injury” at the 2012 American Society for Biochemistry and Molecular Biology, Mitochondria Symposium: East Lansing, Michigan USA. Awarded to highest ranked presentation at conference.
“Best Abstract Award” for the presentation entitled “Mitochondrial Opa1 Dissociation Mediates Cristae Remodeling and Cytochrome C Release Following Global Brain Ischemia” at the 7th annual Resuscitation Science Symposium: 2009 American Heart Association Scientific Sessions. Orlando, Florida USA.
"Award for Outstanding Academic and Research Performance”, Wayne State University School of Medicine Honors Convocation.
Wayne State University
Institutional Animal Care and Use Committee (IACUC), Wayne State University-Vice Chair.
Brain@wayne – steering committee member and chair of student committee.
Henry Ford Hospital Research Symposium-Judge.
Institutional Animal Care and Use Committee (IACUC), Wayne State University-Member.
Wayne State University Graduate Exhibition-Judge.
Wayne State University School of Medicine
Cardiovascular Research Institute, Wayne State University- Student Development Program- Chair
2012 - present
Cardiovascular Research Institute, Wayne State University- Promotion and Tenure Committee- Member
Wayne State University School of Medicine Graduate Research Day-Judge
Citation #’s from Google Scholar, bold qualify for H Index, H = 12 Student/Trainee authorships *
1. Kumar R, Bukowski MJ*, Wider JM*, Reynolds CA*, Calo L*, Lepore B*, Tousignant R*, Jones M, Przyklenk K, Sanderson TH. Mitochondrial Dynamics Following Global Cerebral Ischemia. Molecular and Cellular Neuroscience. Mol Cell Neurosci. 2016 Aug 24; (16) 30132-4.
Citations - 2
2. Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: Implications for AMP Kinase. J Biol Chem 2016; M116. 744664. Contributed experiments in kidney in vivo analysis.
3. Sanderson TH, Raghunayakula S, Kumar R. Neuronal Hypoxia Disrupts Mitochondrial Fusion. Neuroscience. 2015 Jun 3;301:71-78.
Citations – 6
4. Sanderson TH, Raghunayakula S, Kumar R. Release of Mitochondrial Opa1 Following Oxidative Stress in HT22 Cells. Molecular and Cellular Neuroscience. 2015 Jan 8;64C:116-122.
Featured as cover of issue – Citations - 9
5. Sanderson TH, Gallaway M*, Kumar R. Unfolding the Unfolded Protein Response: Unique Insights into Brain Ischemia. International Journal of Molecular Science. Invited contribution to special issue on “Neurological Injuries’ Monitoring, Tracking and Treatment”. 2015 Mar 30;16(4):7133-7142.
Citations – 12
6. Przyklenk K, Sanderson TH, Hüttemann M. Clinical Benefits of Remote Ischemic Preconditioning: New Insights…and New Questions. Circulation Research. 2014 Feb 28;114(5):748-50. – Contributed section on remote conditioning and miRNA Citations - 2
7. Hüttemann M, Doan JW, Goustin AS, Sinkler C*, Mahapatra G, Shay J, Liu J, Elbaz H, Grossman LI, Ding Y, Zielske SP, Malek M, Sanderson TH, Lee I. Regulation of Cytochrome in Respiration, Apoptosis, Neurodegeneration and Cancer – the Good the Bad and the Ugly. Cytochrome C: Electrochemistry, Biological Functions and Pathophysiological Implications. 2014. March 1-38. – Contributed section on cytochrome c in apoptosis and neurodegeneration
8. Sanderson TH, Mahapatra G, Pecina P, Ji Q, Yu K, Sinkler C*, Varughese A, Kumar R, Bukowski M*, Tousignant RN*, Salomon AR, Lee I, Hüttemann M. Cytochrome c is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment. PLoS one. 2013. Nov 5;8(11).
Citations - 16
9. Sanderson TH, Reynolds CA*, Kumar R, Przyklenk K, Hüttemann M. Molecular Mechanisms of Ischemia-Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation. Molecular Neurobiology. 2013. Feb;47(1):9-23. As of May/June 2016, this “highly cited paper” received enough citations to place it in the top 1% of its academic field based on a highly cited threshold for the field and publication year - Thompson Reuters, Web of Science.
Citations – 189
10. Sanderson TH and Wider JM*. 2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia. Journal of Visualized Experiments. 2013. Jun22;(76).
Citations - 8
11. Lagina AT, Calo L*, Deogracias M, Sanderson TH, Kumar R, Wider J, Sullivan JM. Combination Therapy with IGF-1 and Hypothermia Synergistically Improves Outcome after Transient Global Ischemia in the Rat. Academic Emergency Medicine. 2013 Apr;20(4):344-51.
12. Calo L*, Dong Y, Kumar R, Przyklenk K, Sanderson TH. Mitochondrial dynamics: an emerging paradigm in ischemia/reperfusion injury. Current Pharmaceutical Design. 2013. 19(39):6848-57.
Citations - 17
13. Reynolds CA*, Hüttemann M, Przyklenk K, Sanderson TH. Hypoxia-induced damage to the adult and immature brain: molecular mechanism of oxidative damage and the need for targeted therapeutic intervention. Hypoxia: Causes, Types and Management. Jan. 2013. 346:7-10.
14. Hüttemann M, Lee I, Grossman LI, Doan JW, Sanderson TH. Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease. Adv Exp Med Biol. 2012. 748:237-64.
Citations - 63
15. Hüttemann M, Helling S, Sanderson TH, Sinkler C, Samavati L, Mahapatra G, Varughese A, Lu G, Liu J, Ramzan R, Vogt S, Grossman LI, Doan JW, Marcus K, Lee I. Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim Biophys Acta. 2012 Apr; 1817(4):598-609. Contributed ischemia/reperfusion section.
Citations - 129
16. Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Grossman LI. Cytochrome c oxidase subunit 4 isoform 2 knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB Journal 2012. Sep;26(9):3916-30. Contributed section on mouse pathology analysis.
Citations - 25
17. Hüttemann M, Pecina P, Rainbolt M, Sanderson TH, Kagan VE, Samavati L, Doan J, Lee I. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis. Mitochondrion. 2011. May;11(3):369-81. Contributed section on apoptosis.
Citations - 197
18. Sanderson TH, Deogracias MP, Krause GS, Kumar R. PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins. Neuroscience. 2010;169(3):1307-14.
Citations – 19
19. Hazelton JL, Balan I, Elmer GI, Kristian T, Rosenthal RE, Krause G, Sanderson TH, Fiskum G. Hyperoxic Reperfusion after global cerebral ischemia promotes long-term hippocampal neuronal death and neurologic impairment. J Neurotrauma. 2010;27(4):753-62. Contributed section using rat model to test hyperoxic reperfusion.
Citations – 54
20. Sanderson TH, Kumar R, Murariu-Dobrin AC, Page AB, Krause GS, Sullivan JM. Insulin induces phosphatidylinositol-3 kinase-dependent phosphorylation of Akt in vulnerable neurons after transient global brain ischemia. Neurol Res. 2009; 31(9):947-58.
Citations - 34
21. Sanderson TH, Kumar R, Sullivan JM, Krause GS. Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding. J Neurochem. 2008;106(3):1248-58.
Citations - 34
1. Sanderson TH. Insulin-mediated suppression of cytochrome c release from mitochondria after transient brain ischemia. Ph.D. Dissertation. December 2006.
1. Reynolds CA, Gruley E, Strubakos C, Hüttemann M, and Sanderson TH. Non-invasive mitochondrial modulation: a novel approach to reduce cerebral injury following neonatal hypoxia-ischemia. Poster presentation at Neuroscience 2016, San Diego, CA, USA, Nov, 2016.
2. Bukowski M, Calo L, Przyklenk K, Kumar R, Sanderson TH. Mitochondrial Dynamics during Global Cerebral Ischemia/Reperfusion Injury. Oral presentation at Neuroscience 2015 – Molecular Mechanisms Associated with Ischemia Symposium, Chicago, IL, USA, Oct, 2015. Selected to Chair Symposium.
3. Bukowski M, Reynolds C, Wider J, Gruley E, Przyklenk K, Hüttemann M, Sanderson TH. Modulation of Mitochondrial Function with Specific Infrared Light Wavelengths: A Novel Approach to Reduce Cerebral Reperfusion Injury in the Adult and Neonatal Brain. Oral presentation by M. Bukowski (Graduate Student) at Neuroscience 2015, Chicago, IL, USA, Oct, 2015.
4. Sanderson TH, Wider J, Reynolds CA, Lepore B, Przyklenk K, Hüttemann M. Modulation of Cytochrome c Oxidase Activity with Specific Infrared Light Wavelengths: Non-invasive Therapy for Reperfusion Injury. Oral presentation at American Heart Association, Resuscitation Science Symposium - Best Original Resuscitation Science, Chicago 2014. Circulation 130 (Suppl 2). Selected for “Young Investigator Award”.
5. Sanderson TH, Bukowski MJ, Calo L, Lepore B, Przyklenk K, Kumar R. Mitochondrial Dynamics during Cerebral Ischemia/Reperfusion Injury: The Role of Opa1 in Cytochrome c Release. Poster at American Stroke Association, International Stroke Conference, Nashville, TN USA, Feb, 2015. Stroke 46 (Suppl 1), AWP234-AWP23
6. Sanderson TH, Lee I, Kumar R, Przyklenk K, Grossman L, Hüttemann M. Role of Cytochrome c Oxidase Subunit 4- Isoform 2 in Neuronal Susceptibility to Lethal Ischemia/Reperfusion-Induced Injury. Oral presentation at American Stroke Association, International Stroke Conference, February 2012. Stroke 43 (Suppl 1), A26-A26
7. Sanderson TH, Undyala VV, Przyklenk K, Kumar R. Molecular Mechanisms of Cytochrome c Release following Ischemia-Reperfusion: Role of Drp1 Translocation and Increased Mitochondrial Fission. Presented as a poster at American Heart Association, Scientific Sessions-Resuscitation Sciences Symposium, November 2010. Circulation. 2010;122:A161
8. Sanderson TH, Deogracias MD, Wang J, Powers FP, Fardous Y, Sullivan J, Kumar R. Mitochondrial Opa1 Dissociation Mediates Cristae Remodeling and Cytochrome C Release Following Global Brain Ischemia. Presented as a poster at American Heart Association, Scientific Sessions-Resuscitation Sciences Symposium, November 2009. Circulation 2009;120 (Suppl II): S1446.
9. Hüttemann M, Sanderson TH, Whittaker P, Wider J, Lee I, Przyklenk K. Non- pharmacologic modulation of mitochondrial function: a novel strategy to attenuate lethal reperfusion injury in brain and heart. Oral presentation at American Heart Association, Scientific Sessions, November 2009. Circulation 2009;120 (Suppl II):S641.
10. Sanderson TH, Deogracias MP, Nangia KK, Wang J, Kumar R. PERK activation following global brain ischemia is independent of unfolded proteins. Presented as a poster at the XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function. Chicago, Illinois USA, June 2009. J Cereb Blood Flow Metab 2009: 29, S407
11. Sanderson TH, Wright JL, Krause GS, Kumar R. Insulin or IGF-1 blocks cytochrome c Release from mitochondria following global brain ischemia. Abstract EMF-4. Ann Emerg Med. 2006;48(4):11A
MAJOR PROFESSIONAL SOCIETIES
American Heart Association- Member of Stroke Counsel and Council on Cardiopulmonary, Critical Care, Perioperative & Resuscitation.
Society for Neuroscience.