Jonathon Sullivan, M.D., Ph.D.

Jonathon Sullivan, M.D., Ph.D.

 Clinical Associate Professor

jsulliva@med.wayne.edu

Jonathon Sullivan, M.D., Ph.D.

Office Phone

313-993-5707

Office Location

550 East Canfield
51.1 Lande MRB
Detroit, MI 48201

Education

Wayne State University
Department of Physiology
Detroit, MI
Ph.D.
December 1998

University of Arizona College of Medicine
Tucson, Arizona
Doctor of Medicine
1988-1992
 

Arizona State University
Tempe, Arizona
1986-1988

Glendale Community College
Glendale, AZ
1984-1986

 

Education – Degrees, Licenses, Certifications

M.D., Ph.D.

Residency

Residency in Emergency Medicine
Wayne State University / Detroit Medical Center
Detroit, MI
1992 - 1995

Chief Resident
1994 - 1995

Fellowships

Research Fellowship in Emergency Medicine
Wayne State University / Detroit Medical Center
Detroit, MI
1995 - 1997

Prior Appointments

FACULTY APPOINTMENTS

Associate Director of Basic Science Research
Department of Emergency Medicine
Wayne State University
5/2007 – present

Graduate Faculty
Wayne State University School of Medicine
3/2005-6-2005

Clinical Assistant Professor
Department of Emergency Medicine
Wayne State University
Detroit, MI 7/2005 – present

Assistant Professor
Department of Emergency Medicine
Wayne State University
Detroit, MI
7/1/97-6/2005

HOSPITAL OR PROFESSIONAL APPOINTMENTS

Attending Physician
Department of Emergency Medicine
Detroit Receiving Hospital
1995-present

Attending Physician
Department of Emergency Medicine
Detroit Riverview Hospital
1995-1997

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Courses taught

TEACHING

  1. Years at Wayne State University - 20
  2. Courses Taught at Wayne State University

Medical Students

  • Year I Pulmonary Function Lab Instructor, 1995 - 1998

Residents/Fellows

  • Clinical Instructor, Department of Emergency Medicine, Detroit Receiving Hospital, 1995-present
  • Teaching Associate, Emergency Medicine Research Elective, 1995-2012
  • Emergency Medicine Didactic Conference: Advanced Fundamentals Series, 1997-2001
  • Ethics in Emergency Medicine Lecture Series, 2013-2016
  • Resident Academic Project Coordinator, 2015-Present
  • Clinically Oriented Physiology Lecture Series, 2014 - 2016

Course or curriculum development

  1. Developed lecture on Regulation of Transcription and Translation for Emergency Medicine Residents, 1997
  2. Developed lecture on Regulation of the Cell Cycle for Emergency Medicine Residents, 1998
  3. Emergency Care of the Victim of Sexual Assault—previously invited lecture for AWMA, now integrated into first year curriculum for 1999-present.
  4. Developed 2-hour evidence-based review of Diagnosis and Treatment of Thromboembolic Disease in the Emergency Department. Published on-line as web presentation.
  5. Developed 1-hour evidence-based review, Management of DKA in the Emergency Department. Available on-line at www.NeverScience.com
  6. Developed 2-hour intensive review for Advanced Neurophysiology (PSL 7660): Apoptosis, Growth Factors and Neuronal Death. Also available online as an Interactive web presentation at www.neverscience.com.
  7. Developed interactive web presentation: Mapping the Wild Genome. Available online.
  8. Developed 1-hour orientation lecture for PGYI Emergency Medicine Residents: Emergency Management of Acute Ischemic Stroke
  9. Developed 1-hour orientation lecture for PGYI Emergency Medicine Residents: Emergency Management of Traumatic Brain Injury
  10. Developed 1-hour lecture for Emergency Medicine Residents: The Future of Emergency Medicine
  11. Developed integrated curriculum for WSU Emergency Medicine Cerebral Resuscitation Fellowship

Course materials (unpublished)

  1. Review article on Regulation of Transcription and Translation 1997
  2. Review article on Regulation of the Cell Cycle 1998
  3. Review on Emergency Care of the Victim of Sexual Assault 1996 (updated March 2000)
  4. Review on Esophageal Emergencies 1995
  5. Review of Toxic Shock Syndrome 1995
  6. Review of Rapid Sequence Induction 1995
  7. Review of Esophageal Emergencies 1997
  8. Review of Thromboembolic Disease 2000
  9. Review of Thrombolytics in Stroke 2000
  10. Management of Acute Ischemic Stroke 2000
  11. Management of Traumatic Brain Injury 2000
  12. Mapping the Wild Genome 2000
  13. Growth Factors, Apoptosis and Neuronal Death 2000, revised December 2002
  14. The Quantum Brain, December 2000
  15. The Future of Emergency Medicine, June 2006
  16. Introduction to Brain Ischemia, February 2008
  17. Acute Diarrhea, March 2008
  18. Acute Diarrhea in Immunocompromised Patients, June 2008
  19. Pathophysiology of Brain Ischemia June 2009
  20. Hyperkalemia 2012.
  21. Hyponatremia 2013.
  22. The Philosophy of Ethics in Emergency Medicine 2013.
  23. Clinically Oriented Physiology Lecture Series (COPS), 2013-2016.
  24. Ethics in Emergency Medicine Lecture Series, 2013-2016
  25. MCES Learner: Moodle/SCORM-based electronic learning platform commissioned by Medical Center Emergency Services for online instruction of staff clinicians, developed in 2014.
     

 

Accomplishments

HONORS/AWARDS

Distinguished Faculty Teaching Award
Detroit Receiving Hospital Residency in Emergency Medicine
2007

Emergency Medicine Foundation
Young Investigator Award For Excellence in Research and Presentation
1998

Award for Outstanding Academic Performance
Emergency Medicine Residency
1994

Professional Experience

SERVICE

Scientific Review Committee
American College of Emergency Physicians
2001-2007 & 2008-present

Grant Review Committee
Society for Academic Emergency Medicine
2002-Present

Publications

 Original observations in refereed journals

1. Sullivan JM, Alousi SS, Hikade KR, Rafols JA, Krause GS, White BC. Insulin induces dephosphorylation of eIF2(P) and restores protein synthesis in vulnerable hippocampal neurons following transient brain ischemia. J Cereb Blood Flow Metab 1999;19:1010- 1019.

2. DeGracia DJ, Sullivan JM, Neumar RW, Alousi SS, Hikade KR, Pittman JE, White BC, Rafols JA, Krause GS. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2. J Cereb Blood Flow Metab 1997;17:1291- 1302.

3. DeGracia DJ, Adamczyk S, Folbe AJ, Konkoly LL, Pittman JE, Neumar RW, Sullivan, JM, Scheuner D, Kaufman RJ, White BC, Krause GS. Eukaryotic initiation factor 2 alpha kinase and phosphatase activity during postischemic brain reperfusion. Exp Neurol 1999;155:221-227.

4. Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2a kinase, PERK. J Neurochem 2001;77:1418- 1421.

5. Owen C, Lipinski C, Page A, White B, Sullivan J, Rafols J, Krause G. Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion. Neurol Res 2006;28:818-821.

6. Sanderson TH, Kumar R, Sullivan JM, Krause GS. Insulin blocks cytochrome c release after brain ischemia. J. Neurochem, 2008 Aug;106(3):1248-58. Epub 2008 Jun 2.

7. Sanderson TH, Murariu-Dobrin AC, Page AB, Krause GS, Sullivan JM. Insulin induces phosphatidylinositol-3 kinase-dependent phosphorylation of Akt in vulnerable neurons after transient global brain ischemia. Neurol Res. 2009 Nov;31(9):947-58.

8. Wang F, Wang Y, Geng X, Asmaro K, Peng C, Sullivan JM, Ding JY, Ding Y. Neuroprotective effect of acute ethanol administration in the rat with transient cerebral ischemia. Stroke 2012; 43(1) 205-10.

9. Lagina AT, Deogracias M, Reed K, Bazzi D, Chepuri R, Foster L, Sullivan JM. The “Refrige-a-RAT-or:” an accurate, inexpensive and clinically relevant small-animal model of therapeutic hypothermia. Acad Emerg Med 2012; 19(4):402-408.

10. Lagina A, Calo L, Deogracias M, Sanderson T, Kumar R, Sullivan JM. Combination Therapy with IGF-1 and Hypothermia Synergistically Improves Outcome After Transient Cerebral Ischemia in the Rat. Accepted, in press: Acad Emerg Med April 2013.

Review articles
1. White BC, Sullivan JM. Apoptosis. Acad. Emerg Med 1998;5:1019-1029.

2. White BC, Sullivan JM, DeGracia DJ, O’Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neuro Sci 2000;179:1-33.

Books and chapters

1. Owen C, Lipinksi C, Page A, White B, Sullivan J, DeGracia DJ, Rafols J, Krause G. Characterization of the eIF2-Assosiated Protein p67 During Brain Ischemia and Reperfusion. In Bazan NG, Ito U, Marcheselli VL, Kuroiwa T, Klatzo I (eds), Maturation Phenomenon in Cerebral Ischemia IV, Berlin Heidelberg, Springer-Verlag, pp. 19-24. 2001.

2. Sullivan, JM. Cerebrovascular Accident. In R. V. Aghababian et al (eds). Essentials of Emergency Medicine, Lippincott Williams and Wilkins, 2005, Second Edition 2009.

3. Sullivan JM, Baker A. The Barbell Prescription: Strength Training for Life After Forty. Aasgaard Press, 2016.

Editorials/Commentaries

1. Sullivan, JM. “Customers, patients, ostriches and turbulence.” Opinion column for
Incision and Drainage at drhem.com, February 2009.

2. Sullivan, JM. “Turkey, Tinea and a Touch of Death.” Opinion column for Incision and Drainage at drhem.com, April 2009.

3. Sullivan, JM. “Politics, Parasites and a Proof of Principle.” Opinion column for Incision and Drainage at drhem.com, October 2009.

4. Sullivan, JM. “Barbell Training is Big Medicine.” Invited evidence-based scientific article on growth factors, resistance training and aging for Starting Strength, commissioned and published by the Aasgard Company. Available online at www.startingstrength.com. September 2011.

5. Sullivan, JM. “The Year in Strength Science 2011.” Invited critical review of 2011 exercise science literature for Starting Strength, published by the Aasgard Company. Available online at www.startingstrength.com. December 2011.

6. Sullivan, JM. “Stopping the Spread of Misinflammation.” Invited review of the physiology and relevant clinical literature on the use of anti-inflammatories and cryotherapy in coaching and sports medicine practice. Commisioned and published by the Aasgaard company. Available online at www.startingstrength.com. August 2012.

7. Sullivan, JM, O’Neil BJ. Into the age of reanimation: promise and challenge in cardiac arrest care. Therapy (2011); 8(6), 673-5.

8. Sullivan, JM. “The Year in Strength Science 2012.” Invited critical review of 2012 exercise science literature for Starting Strength, commissioned and published by the Aasgard Company. Available online at www.startingstrength.com. March 2013.

9. Sullivan, JM: “The Year in Strength Science 2013.” Invited critical review of 2013 exercise science literature for Starting Strength, commissioned and published by the Aasgard Company. Available online at www.startingstrength.com. May 2013.

10. Sullivan JM: “The Greysteel Channel.” Educational videos on healthy aging for the general public, available at youtube.com/greysteel, beginning November 2016.

PUBLISHED ABSTRACTS:

1. DeGracia DJ, Sullivan JM, Neumar R, Hikade K, Alousi S, Pittman J., White B, Rafols J, Krause G. Ser51 Phosphorylation of eukaryotic initiation factor 2 (eIF2) during early post-ischemic brain reperfusion. J Cereb Blood Flow Metab 1997;17 (Supplement 1):S49.

2. Sullivan JM, DeGracia DJ, Neumar RW, Alousi SS, White BC, Rafols JA, Krause GS. Effect of brain ischemia and reperfusion on localization of ser-51(P)eIF-2. Society Neurosci Abstr 1997;23:2181.

3. Sullivan JM, Alousi SS, Hikade KR, Rafols JA, Krause GS, White BC. Insulin induces dephosphorylation of eIF2 and restores protein synthesis in vulnerable hippocampal neurons following transient brain ischemia. Society Neurosci Abstr 1998;28:41.

4. Sullivan JM, DeGracia DJ, Neumar RW, Alousi SS, White BC, Rafols JA, Krause GS. Effect of brain ischemia and reperfusion on localization of ser-51(P) eIF-2. Translational Control 1998, p 261. International Meeting on Translational Control, Cold Spring Harbor, New York, September 1998. Poster presentation.

5. DeGracia DJ, Neumar RW Sullivan JM, Scheuner DL, Konkoly LL,White BC, Kaufman RJ, Krause GS. PKR is not required for phosphorylation of eIF2-alpha during brain reperfusion. Society Neurosci Abstr 1998;24:41.

6. McKeown TR, Goldstein EN, Sullivan JM, Lipinski CA, Rafols JA, White BC, Krause GC. Nuclear Localization and DNA-binding properties of phosphorylated eIF2 in vulnerable hippocampal neurons during reperfusion. Fourth International Workshop on Maturation Phenomenon in Cerebral Ischemia Apoptosis and/or Necrosis, Neuronal Recovery vs. Death, and Protection for Infarction, 1999.

7. Kumar R, Sullivan JM, Konkoly LL, Krause GS, Han A, Chen JJ, DeGracia DJ. eIF-2 phophsorylation following cerebral ischemia in HRI, eNOS, and nNOS knockout mice. Translational Control 2000, p 203.

8. Kumar R, Azam S, Owen CR, White BC, Sullivan JM, Krause GS, DeGracia DJ. Effectors of eIF2 alpha phosphorylation following cerebral ischemia. J Cereb Blood Flow Metab 2001:1;S101. Meeting of the International Society for Cereberal Blood Flow and Metabolism, June 2001. Poster presentation.

9. Sullivan JM, Francis T, Kumar R, Owen C, DeGracia DJ, Kassab D, White BC, Krause GS. Insulin induces phosphorylation of Akt and Bad after transient global brain ischemia.
J. Cereb Blood Flow Metab 2001:1;S101. Meeting of the International Society for Cereberal Blood Flow and Metabolism, June 2001. Poster presentation.

10. Sullivan JM1,2, Sanderson TH1,2, Murariu-Dobrin AC1,2, Owen CR1,2, Page AB3, Krause GS1,4. Insulin induces phosphorylation of Akt and Bad in vulnerable hippocampal neurons after transient global brain ischemia in a wortmannin-sensitive manner. Research Forum, Scientific Assembly of the American College of Emergency Physicians, October 2003.

11. Sanderson TH, Murariu-Dobrin A, Page A, Krause GS, Sullivan JM. Insulin induces PI3- K-dependent phosphorylation of Akt in vulnerable neurons after transient globa brain ischemia without translocation of Bad or Bim. SAEM Midwest Regional, September 2007.

12. Sanderson TH, Kumar R, Sullivan JM. High-dose insulin prevents cytochrome c release and preserves CA1 structure and function following transient brain ischemia. SAEM Midwest Regional, September 2007.

13. Lagina AT, Kumar R, Sanderson T, Reed K, Sullivan JM. A clinically relevant, precise and noninvasive model of therapeutic hypothermia in the rat. International Symposium on Cerebral Blood Flow and Metabolism, June 2009.

14. Sullivan JM, Lagina AT, Kumar RF, Wang J. Hypothermia alters protein SUMOylation during early reperfusion after focal ischemia in the rat. International Symposium on Cerebral Blood Flow and Metabolism, June 2009.

15. Lagina A, Sanderson T, Kumar R, Foster L, Jeffery T, Bazzi D, Chepuri R, Reed K, Wider J, Sullivan J. A clinically relevant model of hypothermia: toward combination therapy for cerebral ischemia. Scientific Assembly of the American College of Emergency Physicians, October 2009.

16. Lagina A, Foster L, Sanderston T, Kumar R, Deogracias M, Tousignant R, Wider J, Sullivan J. Combination Therapy with IGF-1 and Hypothermia Synergistically Improves Outcome After Transient Global Brain Ischemia in the Rat. Scientific Assembly of the American College of Emergency Physicians, October 2010.

Other Information

MAJOR PROFESSIONAL SOCIETIES

American College of Emergency Physicians
American Academy of Emergency Physicians
Society for Academic Emergency Medicine
American Association for the Advancement of Science
National Strength and Conditioning Association