Rita Kumar, Ph.D.

Rita Kumar, Ph.D.

 Assistant Professor

rkuma@med.wayne.edu

Rita Kumar, Ph.D.

Office Phone

313-577-5738

Office Location

550 E. Canfield
Lande Building, Rm 458
Detroit, MI 48201

Education

Graduate:

Post-Doctoral Fellow/Instructor (Research)
Departments of Emergency Medicine and Physiology
Wayne State University
Detroit, MI
2/2002-6/2004

Doctor of Philosophy
Major: Physiology; Minor: Molecular Biology
Wayne State University
Detroit, MI
09/1998-12/2001

Master of Science
Major: Biology; Minor: Genetics
Wayne State University
Detroit, MI
09/1997-05/1998

Baccalaureate:

Bachelor of Science
Major: Biology
University of Windsor
Windsor, Ontario, Canada
09/1991-05/1995

POSTGRADUATE TRAINING

Leadership Summit for Women
Leading the Future of Academic Medicine & Healthcare
University of Michigan-Linkage
03/ 2015

New England Biolabs Inc./Smith College
Molecular Biology Summer Workshop
06/2006

Education – Degrees, Licenses, Certifications

Ph.D.

Prior Appointments

FACULTY APPOINTMENTS

Assistant Professor, Primary Appointment
Department of Emergency Medicine
06/2004 – present

Assistant Professor, Joint Appointment
Department of Physiology
Wayne State University
06/2004 – present

PROFESSIONAL APPOINTMENTS

Primary Member
Cardiovascular Research Institute
Wayne State University-School of Medicine
Detroit, MI
2008 – present

 

Courses taught

Teaching at Wayne State University

Undergraduate students

Physiology Department
Fundamentals of Human Physiology, PSL 3220
Neurophysiology
2004-2005

Graduate students

Graduate Programs Department - Biomedical Science Program
Physiologic Anatomy, BMS 6550
Cardiovascular System, Abdominal muscles, Reproductive System
2004-2016

Department of Special Programs - Post-baccalaureate
Cell Physiology
Renal Physiology
2002

Department of Special Programs - Post-baccalaureate
Physiology: Muscle Physiology
Neurophysiology
2001

Medical students

Physiology Laboratory
Muscle Physiology, Cardiovascular Physiology
2011-2013

Accomplishments

HONORS/AWARDS

American Heart Association-Scientific Sessions Best Abstract Award
2009

Travel Award, Department of Physiology
Wayne State University School of Medicine
Detroit, MI
2000

High Honors on Ph.D. Competence Exam
Department of Physiology
Wayne State University School of Medicine
Detroit, MI
1999

Wayne State University School of Medicine
Interdisciplinary Biomedical Science Fellowship
1998-2001

 

Professional Experience

SERVICE

Wayne State University

School of Medicine

Women In Medicine and Science-Peer Mentoring Group Committee Member
2016

Invited Judge-Graduate Student Research Day
Wayne State University-School of Medicine
Detroit, MI
2007-2016

University

Faculty lecturer- your Brain on STEM
Gaining Options-Girls Investigate Real Life (GO-GIRL) an NIH supported program
-objective to expose adolescent girls to STEM careers
2015-2016

Wayne State University Graduate Exhibition Judge
2014-2016

Academic Senate-member-at-large
2009-2013

Academic Senate-Budget Committee
2009-2013

Affiliate Medical Organizations

Henry Ford Hospital Research Symposium-Judge
2014-2016

Professional

Society for Academic Emergency Medicine
Abstract Reviewer
2011-2012

Society for Academic Emergency Medicine
Research Committee
2006-2010

Community

Presentation to Brownell Middle School
Grosse Pointe Park, MI; Grades 7 (~200 students)
Lecture on how the Brain functions and Basic Neuroanatomy
2016

Presentation to St. Clare of Montefalco Catholic School
Grosse Pointe Park, MI
Grades 6-8
Basic Neuroanatomy Lecture and encouraging students to pursue Science and Health-related professions
2015-2016

Scholarly Service

Grant Review Committee

International

The French National Research Agency (ANR)
2016

National

NIH/NINDS Review Panel for Emerging Technologies and Training in Neurosciences (ETTN)
2015-2016

Ad hoc member, Department of Defense, Congressionally Directed Medical Research Programs (CDMRP)Peer Reviewed Medical Research Program (PRMRP)
2015-2016

American Heart Association-Basic Cell-Membranes and Subcellular organelles (National level) BSO 1 & 2-full member
2014-2016

Editorial Board Membership

Open Journal of Modern Neurosurgery
2011-2016

Remedy Open Access-Cardiology
2016

Manuscript Reviewer

Neuroscience
2015-2016

International Journal of Molecular Science
2015-2016

Brain Sciences
2015-2016

Academic Emergency Medicine
2014

Molecular Neurobiology
2013-2015

Frontiers in Genomic Endocrinology
2013-2016

Journal of Neurochemistry
2013-2014

Journal of Neuroscience Research
2013-2014

Neurobiology of Disease
2009-2016

Journal of Experimental Stroke & Translation Medicine
2008-2010

Resuscitation
2006-2016

 

Publications

Peer-Reviewed Publications

1. Kumar R, Bukowski MJ, Wider JM, Reynolds CA, Calo L, Lepore B, Tousignant R, Jones M, Przyklenk K, Sanderson TH. Mitochondrial dynamics following global cerebral ischemia. Mol Cell Neurosci. 2016 Oct;76:68-75.

2. Raghunayakula S, Subramonian D, Dasso M, Kumar R, Zhang XD. Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. PLoS One. 2015 Dec 7;10(12):e0144508.

3. Ikonomov OC, Sbrissa D, Compton LM, Kumar R, Tisdale EJ, Chen X, Shisheva A. The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation. J Biol Chem. 2015 Sep 24. pii: jbc.M115.669929.

4. Sanderson TH, Raghunayakula S, Kumar R. Neuronal hypoxia disrupts mitochondrial fusion. Neuroscience. 2015 Jun 3. pii: S0306-4522(15)00529-1

5. Sanderson TH, Gallaway M, Kumar R. Unfolding the Unfolded Protein Response: Unique Insights into Brain Ischemia. Int J Mol Sci. 2015; 16(4):7133-7142.

6. Sanderson TH, Raghunayakula S, Kumar R. Release of Mitochondrial Opa1 following Oxidative Stress in HT22 cells. Molecular and Cellular Neuroscience. 2015; 64:116- 122.

7. Sanderson TH, Mahapatra G, Pecina P, Ji Q, Yu K, Sinkler C, Varughese A, Kumar R, Bukowski MJ, Tousignant RN, Salomon AR, Lee I, Hüttemann M. Cytochrome c is tyrosine 97 phosphorylated by neuroprotective insulin treatment. PLoS one. 2013; 8(11):e78627.

8. Calo L, Dong Y, Kumar R, Przyklenk K, Sanderson TH. Mitochondrial Dynamics: an Emerging Paradigm in Ischemia-Reperfusion Injury. Current Pharmaceutical Design. 2013; 19:6848-57.

9. Sanderson TH, Reynolds CA, Kumar R, Przyklenk K, Hüttemann M. Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol Neurobiol. 2013; 47(1):9-23.

10. Lagina A, Calo L, Deogracias M, Sanderson TH, Kumar R, Sullivan JM. Combination Therapy with IGF-1 and Hypothermia Synergistically Improves Outcome After Transient Cerebral Ischemia in the Rat. Academic Emergency Medicine. 2013; 20(4):344-51.

11. Sanderson TH, Deogracias MP, Nangia KK, Wang J, Kumar R. PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins. Neuroscience. 2010; 169(3):1307-14.

12. Sanderson TH, Kumar R, Murariu-Dobrin AC, Page AB, Krause GS, Sullivan M. Insulin induces phosphatidylinositol-3 kinase-dependent phosphorylation of Akt in vulnerable neurons after transient global brain ischemia. Neurol Res. 2009; 31(9):947-58.

13. Miller CD, Kumar R, Storrow AB. Alignment of emergency medicine research efforts with Clinical and Translational Science Awards. Acad Emerg Med. 2008; 15(7):672-7.

14. Sanderson TH, Kumar R, Sullivan JM, Krause GS. Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding. J Neurochem 2008; 106(3):1248-58.

15. Miller JM, Kumar R, McAllister II JP, Krause GS. Gene Expression Analysis of the Development of Congenital Hydrocephalus in the H-Tx Rat. Brain Res 2006; 1075(1):36-47.

16. Owen CR*, Kumar R*, Zhang P, McGrath BC, Cavener DR, Krause GS. Perk is necessary and sufficient for the large increase in eIF2α(P) phosphorylation immediately after transient brain ischemia. J Neurochem. 2005; 94:1235-1242. (*1st and 2nd authors contributed equally).

17. Page AB, Owen CR, Kumar R, Rafols JA, White BC, DeGracia DJ, Krause GS. Persistent eIF2αP) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons by 4 hours reperfusion after 10 minutes complete brain ischemia. Acta Neuropathol (Berlin) 2003; 106:8-16.

18. Kumar R, Krause GS, Yoshida H, Mori K, DeGracia DJ. Dysfunction of the unfolded protein response during global brain ischemia and reperfusion. J Cerebral Blood Flow Metabol 2003; 23:462-471.

19. DeGracia DJ, Kumar R, Owen CR, Krause GS, White BC. Molecular pathways of inhibited translation during brain reperfusion: implications for neuronal survival or death. J Cerebral Blood Flow Metabol Invited Review. 2002; 22:127-141.

20. Kumar R, Azam S, Sullivan JM, Owen CR, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK. J Neurochem 2001; 77:1418-1421.

Submitted Manuscripts Under Review

1. Mendelson F, Raghunayakula S, Kumar R. Mitochondrial Dynamics following Brain Ischemia. J Neuroscience and Clinical Res In Revision (2017)

 

Published Abstracts

1. TH Sanderson, MJ Bukowski, L Calo, K Przyklenk, R Kumar. Abstract W P234: Mitochondrial Dynamics during Cerebral Ischemia/Reperfusion Injury: The Role of Opa1 in Cytochrome c Release. Stroke 46 (Suppl 1), AWP234-AWP234 2015.

2. Dong Y, Undyala VV, Kumar R, Przyklenk K. Mitochondrial translocation of dynamin-related protein 1 promotes lethal ischemia-reperfusion injury. Circulation 2012; 126: A13470.

3. Sanderson TH, Lee I, Kumar R, Przyklenk K, Grossman L, Hüttemann M. Role of Cytochrome c Oxidase Subunit 4- Isoform 2 in Neuronal Susceptibility to Lethal Ischemia/Reperfusion-Induced Injury. Oral presentation at American Stroke Association, International Stroke Conference, February 2012.

4. Sanderson TH, Undyala VV, Przyklenk K, Kumar R. Molecular Mechanisms of Cytochrome c Release following Ischemia-Reperfusion: Role of Drp1 Translocation and Increased Mitochondrial Fission. Poster Presentation at American Heart Association, Scientific Sessions-Resuscitation Science Symposium, November 2010. Circulation. 2010; 122:A161.

5. Sanderson TH, Deogracias MD, Wang J, Powers FP, Fardous Y, Sullivan J, Kumar R. Mitochondrial Opa1 Dissociation Mediates Cristae Remodeling and Cytochrome c Release Following Global Brain Ischemia. Circulation 2009;120 (Suppl II): S1446.

6. Sullivan J., Lagina A., Kumar R. and Wang J. Hypothermia alters protein sumoylation during early reperfusion after focal brain ischemia in the rat. J Cereb Blood Flow Metab 2009: 29, S752.

7. A. Lagina, K. Reed, R. Kumar and J. Sullivan. A clinically relevant, precise, and noninvasive model of therapeutic hypothermia in the rat. J Cereb Blood Flow Metab 2009: 29, S703.

8. Sanderson TH, Deogracias MP, Nangia KK, Wang J, Kumar R. PERK activation following global brain ischemia is independent of unfolded proteins. J Cereb Blood Flow Metab 2009: 29, S407.

9. Kumar R, Sanderson TH, Krause GS. High-dose IGF-1 prevents increase in cytosolic cytochrome c following transient brain ischemia. Society of Neuroscience 37th Annual Meeting, San Diego, CA. November 2007.

10. Sanderson TH, Kumar R, Sullivan JM, Krause GS. Characterization of and Insulin- signaling Mechanism that Inhibits Intrinsic Apoptosis Following Transient Brain Ischemia. Society of Neuroscience 37th Annual Meeting, San Diego, CA. November 2007.

 

11. Sanderson TH, Wright JL, Krause GS, Kumar R. Insulin or IGF-1 Blocks Cytochrome c Release From Mitochondria Following Global Brain Ischemia. Abstract; 16th Annual Society for Academic Emergency Medicine Regional Meeting, 2006; 48(4):11A.

12. Gary S. Krause, Peichuan Zhang, Cheri R. Owen, Barbara C. McGrath, Rita Kumar, Douglas R. Cavener. The Large Increase in eIF2αPhosphorylation Immediately after Transient Brain Ischemia is Due to PERK. Abstract 209. Translational Control. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, September 2004.

13. Kumar R, Page AB, Sanderson TH, Krause GS, Sullivan JM. Insulin treatment following global ischemia attenuates cytochrome c release during brain reperfusion. Abstract 101.6. 33rd Annual Society for Neuroscience Meeting. New Orleans, LA, November 2003.

14. DeGracia DJ, Kumar R, Krause GS, Montie H, Azam S. Dysfunction of the unfolded protein response following global brain ischemia and reperfusion. Abstract 286. XXIst International Symposium on Cerebral Blood Flow, Metabolism, and Function. Calgary, Canada, July 2003.

15. Kumar R, Montie H, DeGracia DJ. Dysfunction of the unfolded protein response following global brain ischemia and reperfusion. Abstract 3. XXIst International Symposium on Cerebral Blood Flow, Metabolism, and Function. Calgary, Canada, July 2003.

16. Montie H, Kumar R, DeGracia DJ. Effects of Neuronal Differentiation on the Expression of the Unfolded Protein Response. J Cereb Blood Flow and Metab 2003; 23,3-3.

17. Kumar R, DeGracia DJ. Ire1α is activated in rat cerebral ischemia and reperfusion and cultured neuroblastoma NB104 cells. Translational Control. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, September 2002.

18. Kumar R, Azam S, Owen CR, White BC, Sullivan JM, Krause GS, DeGracia DJ. Effectors of eIF2 alpha phosphorylation following cerebral ischemia. J Cereb Blood Flow and Metab 2001; 21 (1), S101.

19. Sullivan JM, Francis T, Kumar R, Owen C, DeGracia DJ, Kassab D, White BC, Krause GS. Insulin induces phosphorylation of Akt Bad after transient global brain ischemia. 2001; 21(1), S162.

20. Kumar R, Sullivan JM, Konkoly LL, Krause GS, Han A, Chen JJ, DeGracia DJ. eIF2α phosphorylation following cerebral ischemia in HRI, eNOS and nNOS knockout mice. Translational Control. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, September 2000.

 

Book Authorships, and Chapters

Kumar R. Causal Mechanisms of eIF2α Phosphorylation During Brain Reperfusion. Ph.D. Dissertation 2002.

Other Information

MAJOR PROFESSIONAL SOCIETIES

American Heart Association-Stroke Council Member
2008-present